Abstract: Multi-year regional trial is used to study the classification criteria and the adaptability of largespike wheat varieties in different ecological zones. The results showed that it was difficult to reflect the common characteristics of these varieties and their individual characteristics of spike according to single ear weight, spike length, the number of spikelet and the annual value of one area; the large-spike wheat varieties had strong selectivity for ecological area and the varieties should be selected according to climatic conditions in different regions. Further analysis showed that the large-spike wheat varieties should be variety of spike length more than 8.5 cm and hectare ear number less than 5.7 million, and with prominent single ear weight. The Yangtze River basin should choose the spring varieties with large spike and medium-large spike. Huanghuai wheat area should choose semi-winter varieties with medium-large spike, and southern area of Huanghuai should choose weak spring varieties with large spike. Beijing, Tianjin and other northern areas should not choose large spike varieties.