Abstract: To screen new formula biological agents and accurate & efficient application methods to control Proceras venosatus (Walker) andTryporyza intacta Snellen in the middle and later period, a field test was conducted with 72%Bacillus thuringiensis (Bt)·monosultap WP, 8% cyhalothrin·emamectin benzoate SA and 3.6% cyhalothrin·Bt SA through artificial spraying and unmanned aerial vehicle spraying. Test results showed that 72% Bt·monosultap WP, 8% cyhalothrin·emamectin benzoate SA sprayed in mid-September had good prevention and control effect on the damaged stalks and damaged internodes. 72% Bt·monosultap WP at the dosage of 3000 g/hm2 and 8% cyhalothrin·emamectin benzoate SA at the dosage of 750 mL/hm2 were diluted with 900 kg water per hectare and 15 kg of Haoyang aerial control special additives and water per hectare, which sprayed on leaf surface, and the control effect against borer-damaged stalk rate was above 81.3% and that against borer-damaged internode rate was above 88.6%. This study indicated that 72% Bt·monosultap WP and 8% cyhalothrin·emamectin benzoate SA were ideal new formula biological agents for prevention and control ofP. venosatus andT. intacta in the middle and late period, and could be sprayed artificially or sprayed with unmanned aerial vehicle on leaf surface in mid September.