Abstract: Based on 56 meteorological stations from 1961 to 2016 and MODIS data, The paper aims to analyze the change of dry–wet condition in Qing Hai plateau in order to explain regional response and mechanism of the global changes and improvement of agriculture, The results showed:① The average surface humidity index in Qinghai province was 0.42,which was slightly increasing and its rate of change was 0.002.(10a)<sub>-1</sub>, there was two distinct drought phases from 1961 to 1980a and from 1990 to 2002a, but wet phases from 1981 to 1989a and from 2003 to 2012a.② The humidity in Qaidam basin showed the trend to drought during the period of 1961 to 1985a, the slightly trend to wet in the earlier stage between 1985 and 2001, but later it showed obviously dry, and especially the trend of wetness was clear since 2003a. The tendency of drought showed in earlier stage of Qinghai lake area, and it became wet obviously since 2003a, The wet and dry was frequent turnover in agricultural area, Negative value of humidity index appeared for 22 years, and positive value was 24 years. There was a clear trend of dry from 1961 to 1983a in Qingnan region ,but it became wet after 2002a. ③It has a wet trend in spring in the recent 56 years, Negative value of humidity index appeared for 29 years in spring, and positive value was 27 years. In summer it has a dry trend, Negative value of humidity index appeared for 32 years in spring, and positive value was 24 years, the wet and dry was frequent turnover in fall, and the trend of dry in winter.④There was an obvious dry trend in the south of Qingnan region, De Lingha, Tianjun, Qilian, Wulan from the 1961s to 1970s,and it also dry in Qaidam basin, the east agriculture ,Zhiduo and Geermu region in 1980s,while wet trend in south of Qingnan region was clear.And it became wet in the middle of Qingnan region, Huangzhong, Ledou and Minhe in 1990s, but the wet tendency of the eastern Qingnan region ,the same wet trend since 2000a.⑤The NDVI index was increased obviously in the Qaidam basin and east agriculture ,the southern Qinghai lake and the source of Huanghe river since 2000s, It had a good response to the pattern of dry and wet change in Qinghai province.