Abstract: A comprehensive culture techniques for the Hybrid Rice-Teyou 73 was studied by the method of optimization design. Three influential elements for the culture techniques were leaf age in transplanting（x1），planting density（x2），quantities of nitrogen（x3）.The regression models of three elements with yield，net revenue were established. The results showed that three elements influenced the yield and net revenue. After simulated screening and optimal selection by computer，the comprehensive culture techniques of high yield and efficiency were 5-6 leaves for transplanting，as 175500-282800 hills per hm2，and 140-188kg N per hm2.