The characterization of nutrition in soybean plants and corresponding techniques for fertilizer application were summarized in this article. The amount of major nutrients needed by soybean plant was generally higher than most cereal crops such as rice and wheat under similar grain yield. The absorption and accumulation of the major nutrients (nitrogen, phosphorus, potassium) reached highest during flowering and podding stage. About 40%-60% of the nitrogen in soybean plant was from symbiotic nitrogen fixation with Rhizobia. The N-fixation was considerably influenced by many factors including soil texture, nutrients status and pH. The ratio of nutrients transferred from the vegetative tissues to the grains in soybean was also generally higher than most other crops. Soybean yield could be 2025-4500 kg/hm2 through balanced utilization of N, P, K, Zn and Mo. Nitrogen and phosphorus could increase the protein content while potassium and Zn could increase the oil content. Desirable amount of fertilizers in soybean production would be decided based on the soil nutrient status. Reasonable combination of organic manure with N, P, K, and Rhizobia inoculants was crucial for achieving high yield. Special attention should be paid to the fertilization of the previous crops in terms of improving soil fertility. On soils with moderate fertility, 120 kg N, 60 kg P2O5, 60 kg K2O, 22.5 kg ZnSO4 per hectare would be applied. Fertilizers of P, K, Zn could be applied before field preparation while half of N and Mo could be applied during planting and the rest half could be applied during flowering and podding stage.