Abstract: The paper studied the effect of applying organic residues as nest-fertilizers on growth, yield and quality of flue-cured tobacco in eastern of Henan. The results showed that: the treatments of applying oil seeds and edible oils could promote root growth, and increase yields and values. The treatment of Applying sesame could improve presentation quality of tobacco leaves, harmonize chemical components, and heighten the ratio of input to output.And applying soybean milk and edible oils could significantly increase the yield and raise oil composition.