Abstract: The analysis adopted Quadratic Saturation D-the optimum design. Effect of nitrogen and density on high yield of wheat in Huaibei was analyzed. Results were shown that effect of increasing production of nitrogen was over density, and the interaction was negative effect. Adding the amount of nitrogen fertilizer applied could increase evidently the number of per hm2 and of grain per panicle. Adding density could increase the number of panicle per hm2 too. But 1000 grain-weight could drop because both two added. The measures for highest yield-level of 8358.3kg/hm2 were as following: N 269.9kg/hm2; density 2.31×106plant/hm2. And idealist yield-structure was: 5.85×106panicle/hm2; 37.9grain/panicle; 1000 grain-weight 39.2g. The reasonable yield when the application of nitrogen range was 255.9~287.3kg/hm2 and density 2.285×106~2.467×106plant/hm2.