Abstract: Abstract: Three medicine constituent contents (indirubin; indigotin; ketone ) of Baphicacanthus cusia(Nees)Bremek leaves and stems in three different origins gathered from different periods were analyzed by means of HPLC detemination.The results showed that: contents of Baphicacanthus cusia(Nees)Bremek medicine constituents are changed with the seasons. Indirubin and indigotin content have reached the maximum value in November, it is the best period to extract indirubin and indigo , but it is the best period for ketone extraction in October. Therefore, the medicine material of Baphicacanthus cusia(Nees)Bremek can be extracted in accordance with the different optimum medicine constituent period.