Abstract: Abstract：This experiment was to observe the influence of QFM preparation on hemodynamics and endothelium-dependent vasodilation in Dogs.QFM preparation was administrated at the doses of 0.1 ml/kg body weight intravenous in 10 dogs. The changes of homodynamic and levels of serum nitric oxide, plasma endothelin, PGF1α and thromboxane A2 were examined before and after the dogs being administrated with QFM preparation. The results showed that the values of SBP、DBP、MAP and HR hemodynamic parameters in dogs with QFM preparation anesthesia decreased (P<0.05 or P<0.01); while in phase, the level of plasma endothelin（ET）and theomboxane A2（TXA2）decreased (P<0.05 or P<0.01), while the level of serum nitric oxide（NO）and plasma 6-keto- prostacyclin F1α （6-Keto-PGF1α）improved significantly or extremely significant (P<0.05 or P<0.01)，and the ratio of NO/ET and 6-Keto-PGF1α/TXB2 also improved significantly or extremely significant (P<0.05 or P<0.01). The results of this study suggested that endothelium vaso-active factors NO, ET, PGI2, TXA2 might modulate the hemodynamic changes mediated by QFM preparation.