Abstract: The study on nanometer SO42-/TiO2-(Ag,Fe) coated with organic reagent showed that the way that the titanate coupling agents were applied to coat the nanometer SO42-/TiO2-(Ag,Fe) particles efficiently promoted the dispersion and stability of TiO2-based particles in the organic paint system, laid the foundation for the preparation of environmental protection coating with photocatalytic activity. Based on the ingredient ratio experiment for nanometer SO42-/TiO2-(Ag,Fe) photocatalytic coating, we obtained the optimal methodology parameters：photocatalyst of 6%,composite SO42-/TiO2-(Ag、Fe) fluorocarbon resin coating with supercritical CO2 content of 30% was sprayed through the nozzle with 0.4mm diameter under condition of 14MPa, 60℃,which lead to the result that the VOC of coating reduced 43.5%.The degradation rate constant of Rhodamine B by coating film was 3. 84×10-2S-1 , which is more than that by ordinary brush by 17.8%. Many kinds of hardly-degraded organic compound such as helianthin B, fuchsin, phenol,also can be mineralized entirely by this kind of coating film, moreover, the photocatalytic activity of degradating Rhodamine B did not decrease obviously after 5 cycle runs, Rhodamine B can be completely mineralized in the 140mins under the visible light.