Abstract: Pesticide residue analysis methods are becoming more useable with the further research work and getting simple, quick, sensitive, low-cost and easy to use. Due to high sensitivity，reliable identification and multiresidues detection, GC-MS has been widely used. Normally GC-MS method includes extraction, purification and analysis of pesticide residues. Often used sample preparation means have liquid-liquid Extraction, Solid Phase Extraction (SPE), Solid Phase Micro-Extraction (SPME), Gel Permeation Chromatography (GPC), Super-Fluid Chromatography (SFC), Refrigeration, Precipitation and so on. U.S has made a simple and easy sample preparation method, named QuEch-ERS.U.S has developed GC-MS analysis method for 251 pesticides and their metabolite on fruits and vegetable, Japan has established fast screening method for 101 pesticides by GC-MS too. Otherwise, GC-MS is also used for fatty food[3] and wine pesticide analysis. Although there already have some research works on pesticide residue analysis in our country, the standard methods almost use conventional instrument, such as GC, LC. GC-MS is only used for result confirmation, not for multiresidue analysis.