Welcome to Chinese Agricultural Science Bulletin,

Chinese Agricultural Science Bulletin ›› 2010, Vol. 26 ›› Issue (13): 53-57.

Special Issue: 生物技术 农业工程

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Production of Taxol and Taxanes by Cell Engineering

Gao Mingbo1,2, Li Xingtai2, Ruan Chengjiang1,2, Fan Shengdi1   

  • Received:2009-12-18 Revised:2010-01-10 Online:2010-07-05 Published:2010-07-05

Abstract:

Taxol is an important anticancer drug and taxanes are metabolic precursors or branch metabolites of taxol with special physiological activity. Pharmaceutical source is the main problem that restrict their application. Cell engineering is a potential technique to produce taxol and taxanes , being environment friendly, easy to control, in accordance with the strategy of sustainable development. Production of Taxol and taxanes in cell culture is reviewed and some advice is given to solve problems in the research.