Abstract: Abstract : Immunohistochemical localization and morphological observation of 5-Hydroxyt- rypamine immunoreactive cells (5-HT cell) in the digestive tract of Rana amurensis have been investigated by the method of the ABC immunohistochemical technique.The results are as follows:the 5-HT cells distribute throughout the digestive tract and their density is the highest in the pylorica part of stomach, followed by the cardia part of stomach, the lowest cell density is found in jejunum. The 5-HT cells have different shapes including round, ellipse, shuttle-like, tapering and other shapes. The 5-HT cells distribute between epithelial cells, at the basal region of epithelial cells, between glandular epithelial cells .The morphological characteristics of 5-HT cells are related with their endocrine, exocrine functions.