Abstract:

Streptomyces can produce a lot of valuable secondary metabolites such as agricultural antibiotic, plant growth hormone, and so on. Gene cloning and recombination of Streptomycetes offers a good possibility to improve secondary metabolite production and exploiting new type antibiotics. The identification of gene clusters of natural products has provided enormous information for the research of their biosynthesis, regulation, and self-resistance mechanisms. This paper reviewed the cloning strategies of the biosynthetic gene clusters of antibiotics.