多溴联苯醚在环境中的残留及毒理学效应研究进展

doi:10.11924/j.issn.1000-6850.casb18030132

摘要/Abstract

摘要： [目的]持久性有机污染物(POPs)是导致环境污染的重要原因,其中多溴联苯醚(PBDEs)又是POPs中的一种,所以全面了解多溴联苯醚在环境中的残留及其对生物体的毒理学效应对于环境的治理和人的健康至关重要。[内容]本文简要归纳了多溴联苯醚在土壤、水体中的残留和相互之间的迁移、转化,总结了多溴联苯醚对生物体的急性毒性和生理生化毒性,并分析了多溴联苯醚对生物体抗氧化系统、机体组织器官的和生物遗传的影响,对接下来进一步的研究提供了依据。[建议]针对多溴联苯醚在环境和生物体中具有高毒性的问题,提出了通过制定更加严格的法律法规来限制多溴联苯醚的使用、加强对含多溴联苯醚废弃物的处理,禁止进口电子垃圾,选取距离居民区较远的地方进行生产等措施,并对发展新型溴代阻燃剂进行了展望。

关键词: 丝状支原体山羊亚种, 丝状支原体山羊亚种, 分离, 鉴定, 羊支原体性肺炎, 福建

Abstract: Persistent organic pollutants (POPs) are a major cause of environmental pollution, and polybrominated diphenyl ethers (PBDEs) are one of the POPs. Therefore, it is important to understand the residue of PBDEs in the environment and its toxicological effects on organisms, for environmental governance and human health. This article briefly summarizes the residue of PBDEs in soil and water bodies, and the migration and transformation between them, and outlines the PBDEs’acute toxicity and physiological and biochemical toxicity in organisms, analyzes the effects of PBDEs on the biological antioxidant system, body organs, tissues, and biological genetic organisms. Aiming at the problems of higher toxicity of PBDEs in the environment and organisms, we put forward that appropriate laws and regulations should be developed to limit the use of PBDEs and strengthen the treatment of wastes containing PBDEs. The study recommends a ban on importing electronic waste, suggests choosing the production place far away from the residential area and so on. The study also discusses the future research on the development of new brominated flame retardant.

中图分类号:

郭楠楠,孟顺龙.,陈家长.. 多溴联苯醚在环境中的残留及毒理学效应研究进展[J]. 中国农学通报, 2019, 35(25): 159-164.

郭楠楠,孟顺龙. and . Polybrominated Biphenyl Ethers: Residual in the Environment and Research Progress on Toxicological Effects[J]. Chinese Agricultural Science Bulletin, 2019, 35(25): 159-164.

参考文献

[1]冯秋园,吴桐,万祎,等.持久性有机污染物(POPs)在水生生态系统中的环境行为[J].北京大学学报:自然科学版,2017,53(3):588-596.
[2]徐奔拓,吴明红,徐刚.生物体中多溴联苯醚(PBDEs)的分布及毒性效应[J].上海大学学报(自然科学版),2017,23(2):235-243.
[3]Jin J, Wang Y, Yang CQ, et al. Polybrominated diphenyl ethers in the serum and breast milk of the resident population from production area,China.[J] Environment international. 2009,35 (7):1048-1052.
[4]Ríos JM, Lana NB, Berton P, et al. Use of wild trout for PBDE assessment in freshwater environments:Review and summary of critical factors[J]. Emerging Contaminants,2015,1(1):54-63.
[5]郁东,王德军,朱文文,等.QuEChERS结合气相色谱-质谱法快速测定职业工人尿液中多溴联苯醚[J].分析测试学报,2017,36(05):640-644.
[6]Parry E, Zota AR, Park JS, et al. Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs):A six-year temporal trend in Northern California pregnant women[J]. Chemosphere,2018,195:777-783.
[7]季麟,高宇,田英.有机磷阻燃剂生产使用及我国相关环境污染研究现况[J].环境与职业医学,2017,34(3):271-279.
[8]UNEP Listing of POPs in the Stockholm Convention(2009).http://chm.pops.int/.
[9]Commission delegated directive(EU)of 31 March 2015 amending Annex Ⅱ to directive 2011/65/EU of the European Parliament and of the council as regards the list of restricted substances[A/OL].2017.
[10]电子电气产品中限用物质的限量要求:GB/T 26572—2011[S].北京:中国标准出版社.2011.
[11]魏孜,朱亚尔,宋瑶,等.基质固相分散-气相色谱/质谱法测定土壤中13种多溴联苯醚[J].浙江大学学报(理学版),2017,44(1):106-111.
[12]薛南冬,陈宣宇,杨兵,等.应用环境多介质逸度模型研究废旧电器拆解区多溴联苯醚的迁移及归趋[J].环境科学,2016,37(11):4326-4332.
[13]Puckett J,Byster L,Westerrelt S, et al. Exporting harm: the high-tech trashing of Asia. http://www.ban.org/E-waste/techno trash final comp.2002:1-54.
[14]伍银爱,孙贝丽.多溴联苯醚在环境介质中的迁移及降解研究[J].广东化工,2017,44(14):149-150+148.
[15]刘敏,殷浩文,陈晓倩,等.多溴联苯醚潜在替代品DOPO-HQ在环境中的稳定性研究[J].环境与职业医学,2017,34(9):772-777.
[16]DeCarlo VJ. Studies on brominated chemicals in the environment. Annals of the New York Academy of Sciences,1979,320(1):678-681.
[17]曾光明,刘敏茹,陈耀宁,等.土壤中多溴联苯醚研究进展[J].土壤学报,2014,51(5):934-943.
[18]郝迪,亦如瀚,吴俣,等.贵屿地区不同类型农业土壤多溴联苯醚的污染特征和暴露评估[J].农业环境科学学报,2015,34(5):882-890.
[19]吴辉,金军,王英,等.典型地区大气中多溴联苯醚和新型溴代阻燃剂的水平及组成分布[J].环境科学,2014,35(4):1230-1237.
[20]李玲,王春雷,蒋友胜,等.深圳市大气中多溴联苯醚污染水平和特征及人体呼吸暴露分析[J].卫生研究,2012,41(5):776-782.
[21]周鹏,于慧娟,赵建华,等.典型污水处理厂中多溴联苯醚的分布特征,迁移及负荷研究[J].环境科学学报,2016,36(4):1248-1259.
[22]Patel G, Dutta S, King TA, et al. Comment on “Partitioning and bioaccumulation of PBDEs and PCBs in Lake Michigan”[J]. Environmental Science Technology,2007,41(9):3391.
[23]王赛赛,宋怿,韩刚,等.多溴联苯醚污染现状研究进展[J].中国农学通报,2017,33(20):149-157.
[24]Chen SJ, Gao XJ, Mai BX, et al. Polybrominated diphenyl ethers in surface sediments of the Yangtze River delta:levels, distribution and potential hydro dynamic influence[J]. Environmental Pollution, 2006,144(3):951-957.
[25]Wang Z, Ma X, Lin Z, et al. Congener specific distributions of polybrominated dphenyl ethers(PBDEs)in sediment and mussel(Mytilus edulis)of the Bo Sea,China[J]. Chemosphere,2009,74(7):896-901.
[26]王晓伟.北方某典型活动区地下水中PBDEs / PFASs的污染特征[J].环境科学与技术,2017,40(7):79-85.
[27]鲍恋君,郭英,刘良英,等.珠江三角洲典型有机污染物的环境行为及人群暴露风险[J].化学进展,2017,29(9):943-961.
[28]张泽光.水环境中十溴联苯醚的生物富集特性及生物毒性研究[D].东华大学,2013.
[29]韩晓芳.固相环境介质中多溴联苯醚的分析测定,生物毒性及生物富集性的研究[D].东华大学,2011.
[30]房宽.两种多溴联苯醚BDE-47和BDE-209对褶皱臂尾轮虫摄食的影响及基于消化酶活性变化的机理探讨[D].中国海洋大学,2013.
[31]赵静,徐挺,白建峰.多溴联苯醚暴露的神经行为效应及其毒理机制[J].生态毒理学报,2017,12(1):52-63.
[32]杨露露,杨雾,伍智蔚,等.计算模拟与光谱法研究4-羟基-2 , 2’ , 3 , 4’-四溴二苯醚与人血清白蛋白的相互作用[J].化学通报,2017,80(2):185-190.
[33]Dingemans MM, De GA, Kleef RG van, et al. Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells.[J]. Environmental Health Perspectives,2008,116(5):637-643.
[34]Kodavanti PRS, Ward TR. Differential effects of Comercial Polybrominated Diphenyl Ether and Polychlorinated Biphenyl Mixtures on Intracellular Signaling in Rat Brain in Vitro [J]. Toxicological Sciences,2005,85(2):952-962.
[35]张易曦,张芹,吉贵祥,等.羟基化多溴联苯醚(OH-PBDEs)在小鼠肝脏S9中的体外代谢研究[J].环境科学学报,2016,36(9):3480-3487.
[36]张易曦,张圣虎,吴永贵,等.羟基化多溴联苯醚(OH-PBDEs)在小鼠肝脏微粒体的体外代谢及对CYP450酶活性的影响[J].生态毒理学报,2016,11(2):693-701.
[37]徐洁,鲜啟鸣.气相色谱-质谱法分析某阻燃剂生产厂周边淡水鱼中的多溴联苯醚及其累积特征[J].岩矿测试,2017,36(4):405-412.
[38]高丹,张圣虎,郭敏,等.四种典型羟基化多溴联苯醚对斑马鱼胚胎的毒性和生物富集性[J].环境科学学报,2018(1).
[39]郝忠锁,常利军,张华俊,等.多溴联苯醚-153染毒对大鼠神经细胞内钙离子浓度及其相关激酶活力和含量影响的体内和体外实验研究[J].环境与健康杂志,2016,33(11):946-949.
[40]Reistad T, Mariussen E, Ring A, et al. In vitro toxicity of tetrabromobisphenol-A on cerebellar granule cells:cell death,free radical formation, calcium influx and extracellual glutamate[J]. Toxicological Sciences An Official Journal of the Society of Toxicology,2007,96(2):268-278.
[41]李云秀,蒋友胜,张建清,等. 2 , 2'' , 4 , 4''-四溴联苯醚通过核受体介导神经毒性作用机制的初步研究[J].癌变.畸变.突变,2017,29(3):172-178.
[42]王赢利,陈建松,阳宇翔,等.十溴联苯醚对秀丽隐杆线虫毒性研究[J].土壤学报,2015,52(5):1116-1123.
[43]Yu L, Liu C, Chen Q, et al. Endocrine disruption and reproduction impairment in zebrafish after long-term exposure to DE-71[J]. Environmental toxicology chemistry, 2014.33(6):1354-62.
[44]奚晶,尤馨悦,曹易懿,等.持久性环境污染物多溴联苯醚的生殖发育毒性[J].伤害医学:电子版,2016,5(3):44-48.
[45]黄婷,段星春,陶雪琴,等.2 , 2'' , 4 , 4''-四溴联苯醚高效好氧降解菌的鉴定及其降解路径[J].环境科学学报,2017,37(12):4705-4714.
[46]Ji K, Choi K, Giesy JP, et al. Genotoxicity of several polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDEs, and their mechanisms of toxicity[J]. Environmental Science Technology,2011,45(11):5003-8.