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中国农学通报 ›› 2022, Vol. 38 ›› Issue (26): 20-26.doi: 10.11924/j.issn.1000-6850.casb2021-0789

所属专题: 生物技术

• 生物科学 • 上一篇    下一篇

甘草内生菌研究概况

尤梦瑶1,2(), 万璐1,2, 闫佳佳1,2, 张赫1,2, 郑春英1,2()   

  1. 1黑龙江大学农业微生物技术教育部工程研究中心,哈尔滨 150500
    2黑龙江大学生命科学学院/黑龙江省普通高校微生物重点实验室,哈尔滨 150080
  • 收稿日期:2020-09-20 修回日期:2021-11-20 出版日期:2022-09-15 发布日期:2022-09-09
  • 通讯作者: 郑春英
  • 作者简介:尤梦瑶,女,1997年出生,黑龙江牡丹江人,硕士,研究方向:食品和药物生物活性挖掘及研发。通信地址:150080 黑龙江省哈尔滨市南岗区学府路74号 黑龙江大学生命科学学院,Tel:0451-86608586,E-mail: youmengyao4u@163.com
  • 基金资助:
    黑龙江大学校企合作横向项目“一株产原儿茶酸的枯草芽孢杆菌”(20170223)

Research Progress on Endophytes from Glycyrrhiza uralensis

YOU Mengyao1,2(), WAN Lu1,2, YAN Jiajia1,2, ZHANG He1,2, ZHENG Chunying1,2()   

  1. 1Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150500
    2Key Laboratory of Microbiology, College of Heilongjiang Province/ School of Life Sciences, Heilongjiang University, Harbin 150080
  • Received:2020-09-20 Revised:2021-11-20 Online:2022-09-15 Published:2022-09-09
  • Contact: ZHENG Chunying

摘要:

甘草内生菌能够产生与宿主植物相同、相似或全新的活性代谢物。采用内生菌发酵法生产甘草次生代谢物对可持续利用甘草资源及筛选新型活性代谢产物具有重要意义。在过去的几十年,尽管人们对甘草内生菌多样性、分离和鉴定、药理作用、次生代谢产物等方面进行了研究,并取得了一定的成果,但还远远不能满足生产的需要,甘草内生菌作为微生物资源是天然产物的重要来源。本研究综述了甘草内生菌及其次生代谢产物的相关研究,归纳出甘草内生菌可产甘草苷、甘草次酸、甘草素等次生代谢产物,并针对甘草内生菌次生代谢产物研究中存在的问题进行了展望,为合理利用甘草内生菌及进一步开发应用提供参考。

关键词: 甘草内生菌, 多样性, 分离及鉴定, 药理作用, 次生代谢产物

Abstract:

Endophytes isolated from Glycyrrhiza uralensis have the potential to produce the same, similar or new active metabolites as the host plants. Secondary metabolites of Glycyrrhiza uralensis produced by fermentation with endophytes are not only important for sustainable utilization of Glycyrrhiza uralensis resources but also significant for screening new metabolites. In the past several decades, although the diversity, isolation and identification, pharmacological action, secondary metabolites and other aspects of endophytes from Glycyrrhiza uralensis have been studied and some achievements have been obtained, it is far from meeting the needs of production. As a microbial resource, endophytes from Glycyrrhiza uralensis are an important source of natural products. The study reviewed the research on endophytes from Glycyrrhiza uralensis and their metabolites, and summarized that endophytes from Glycyrrhiza uralensis could produce liquiritin, glycyrrhetinic acid, liquiritigenin and other secondary metabolites. Meanwhile, according to the problems in the research on secondary metabolites of endophytes from Glycyrrhiza uralensis, the study discussed the prospect and provided certain reference for the rational utilization of endophytes from Glycyrrhiza uralensis.

Key words: endophytes from Glycyrrhiza uralensis, diversity, isolation and identification, pharmacological action, secondary metabolites

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