Abstract:

The aim: To analyze the GnRH post-receptor signal transduction mechanism of the secretion of LH in the mammalian. The way: The GTH cells was stimulated by GnRH at high frequencies after PKC in them was excited or inhibited. LH was detected by ELISA, which was compared with the blank comparison group. Result: The PKC level in GTH cells influences the expression of LH significantly. Conclusion: PKC-Ca2+ is one of the GnRH post-receptor signal transduction pathways that the cells stimulated by GnRH impulse secret LH.