Abstract:

TRAIL could selectively induced the apoptosis of tumor cells, but not the bulk normal had clear toxicity. TRAIL could induced tumor cells to apoptosis through extracellular and intracellular apoptotic pathway, however normal cells could escaped induction of TRAIL through NF-κB mediated, decoying receptors and regulation of c-FLIP. The therapeutic alliance between TRAIL and gene therapy, monoclonal antibody against death receptor, chemotherapy, radiotherapy drugs and proteasome inhibitor could elevated the sensitivity of oncotherapy, meanwhile could reversed the phenomenon of resistance of tumor cells to TRAIL. Therefore, TRAIL might became a new generation antitumor drug to clinical treatment.