Abstract: This paper concluded the achievements and progress in recent 10 years’ in anti-verticillium breeding, indicated that the most effective and feasible method to control verticillium wilt is planting disease-resistant varieties of cotton currently. This paper also analysed the problems in anti-verticillium breeding, and obtained there are about five main problems as follows: (1) Lack of upland cotton anti-source of high resistance; (2)The cycle of anti-verticillium breeding is long and the breeding method is single; (3)The discipline of genetic resistance is not clear and the basis of genetic resistence is narrow; (4) Molecular marker assisted selection exists a lot of limitations in anti-verticillium breeding; (5) The identification methods of anti-verticillium is defected. This paper discussed the way to deal with the problems as follows: (1) Through the distant hybridization, and combined with many generations of backcross and directional selection to create new species ;(2) Using physical chemical and molecular mutagenesis or other means to create new materials; (3)Through the modern biological technology, cultivate new resistance materials; (4) Only importing the resistance gene or using RNAi technology to cultivate resistance plants. At the same time the paper prospected the direction of the future research in anti-verticillium breeding. Researchers have been fostered many new disease-resistance varieties by various breeding ways, but there is lack of varieties which are true and high disease-resistant in cotton producftion.