Abstract: In order to prevent crops bacterial wilt by making full use of agricultural management, reasonable rotation and interplanting technology, combined with the actual agricultural ecology of Yunnan Province, three common weeds in the field of Kunming, Salvia dugesii Fernald, Dature stramonium Datura L., and Commelina communis L. were inoculated with Ralstonia solanacearum in the greenhouse at 28℃, by following Koch's postulates: inoculation, isolation, re-inoculation and re-isolation to verify the bacterial pathogenicity. The results showed that after inoculation, the three weeds produced typical symptoms of bacterial wilt, i.e. black lesion appeared firstly at the inoculation site, and then whole plant wilt, and lots of bacterial ooze were observed. With the consideration of the fact that the three weeds were not infected by R. solanacearum in the nature and enrich the bacterium at their roots, it was inferred that they should be the bacterial potential hosts. These results could provide references to make management strategies for crops bacterial wilt.