Abstract: To determine the effects of rapid release sulphur (RRS) application on winter wheat in Northern China, field trials were conducted respectively in Taian of Shandong province and Cangzhou of Hebei province to evaluate the effects of rapid release sulphur (RRS) on grain yield, seed protein content, sulfur content and economic profit for winter wheat. Five treatments were applied in the experiments: control (0 kg/hm2), sulfur powder with low rate (30 kg/hm2), sulfur powder with high rate (60 kg/hm2), RRS with low rate (30 kg/hm2) and RRS with high rate (60 kg/hm2). Results illustrated that wheat yield was increased by S fertilization on high available sulfur content soil. And the yield responses were affected by the forms and rates of sulfur fertilizer. The RRS increased wheat yield higher than the sulfur powder. The high rate RRS treatment achieved the highest wheat yield at two sites. Comparing with the control, the grain yields were enhanced by 8.3% and 10.1% at Tai’an and Cangzhou sites respectively. Sulfur fertilization improved the sulfur content in wheat grain, but only high rate sulfur treatments at Cangzhou site increased the grain sulfur content significantly. No significant difference was found between two elemental sulfur fertilizers. RRS treatment improved the seed protein content of wheat only for Tai’an site. The low rate RRS treatment yield had higher seed protein content than that in low rate sulfur power treatment. However, there was no significant difference among sulfur treatments at Cangzhou site. Sulfur fertilization led to the economic profit for wheat production. Economic profits were higher for RRS fertilizer than sulfur powder. At Tai’an site, the high rate RRS treatment yielded the highest economic profit (1369 yuan/hm2) and highest value cost ration (10.5). At Cangzhou site, the low rate RRS treatment achieved the economic profit of 1111 yuan/hm2 and highest value cost ratio (16.4). Optimal application of RRS will maintain or improve seed quality while increasing economic profits and wheat grain yield.