Abstract: In order to determine the ‘Lunuo8’ high yield and high efficiency cultivation adaptation of planting density and fertilizer application amount, we use population physiology methods, by two factors and four levels combination experiment design, studied the effect of different planting density and fertilizer on waxy sorghum hybrid ‘Lunuo8’ yield. The results showed that, the density was lower than that of the 112500 strains/hm2, hybrid glutinous sorghum production and increase with the increase of density; but if more than 112500 strains/hm2, hybrid glutinous sorghum production and with the increase of density and reduce. When the amount of nitrogen under pure nitrogen at 187.5 kg/hm2, hybrid glutinous sorghum production with increasing nitrogen rate increased significantly, when the nitrogen content was higher than 187.5 kg/hm2, hybrid glutinous sorghum production with the increase of nitrogen fertilizer amount without significant increase production. As the density increased, the hybrid glutinous sorghum grain number per spike, grain weight, pour 5 leaf area, stem diameter was significantly reduced (small), plant height were significantly higher. As the density increases, the hybrid glutinous sorghum grain number per spike, grain weight, pour 5 leaf area, stem diameter was significantly reduced, plant height was significantly higher. With the increase of nitrogen application amount, hybrid glutinous sorghum grain number per spike, 5 leaf area, stem diameter increased with increasing, 1000-grain weight increased first and then decreased. When the amount of nitrogen than pure nitrogen at 150 kg/hm2, plant height with the increase of nitrogen fertilizer amount and reduce. Thus, when the planting density of 112500 strains/hm2, the fertilization was pure nitrogen at 187.5 kg/hm2, A3B3 for the most appropriate.