Abstract: Seawater quality can affect sea fishing and seafood quality, and thus has received more and more concerns. In order to know the seawater quality in Argopectens irradias fishing area and the influence of seawater on the quality of Argopectens irradias, the quality of surface seawater samples collected from an Argopectens irradias fishing area and un-fishing area in Laizhou Bay at different times was assessed, involved pH and nutrients, chemical oxygen demand (COD), Cu and Zn concentrations. Results showed that, in study area, the inorganic N concentration was high relatively, and approximately reached 0.30 mg/L. Nitrate-N was the main component of inorganic N of seawater in October, which was significantly higher than that in June in which the main inorganic N was ammonia-N (P<0.01). In different sampling sites, the inorganic P concentrations at different times were all less than 0.02 mg/L, and changed insignificantly. COD, Cu and Zn concentrations were all less than the value of the second grade seawater standard, and were significantly higher in October than that in June (P<0.05). The significant positive correlation among COD, Cu and Zn indicated that they probably came from the same polluted source (P<0.01). Argopectens irradias had high bioconcentration capability of Cu and Zn, and the capability of Zn was greater than that of Cu. Although the concentrations of Cu and Zn were both less than the associated standard values, the accumulation extents of Cu and Zn were 1.06 and 0.821, respectively. Therefore, heavy metals accumulation in Argopectens irradias should be aroused more concerns in future.