Abstract: To study the digestive gland tissue structure of Ampullaria gigas and its structural changes in hungry condition, the paraffin section and hematoxylin-eosin staining techniques were used for observation and analysis. The results were as follows: the digestive gland epithelium of A. gigas consisted of digestive cells and basiphil cells. In the digestive gland, there were a large number of black granules mainly located in the crypts of digestive tubules. After continued thirty-day hungriness, the tissue structure of digestive gland of A. gigas changed significantly and the most prominent change was the degeneration of digestive cells. This process was associated with the utilization of digestive gland material, which was a kind of energy metabolism. In conclusion, the digestive gland of A. gigas was not only an important digestion and reserve organ, but also played an important role in survival under starvation.