Abstract: In order to provide a basis for fair using, study the effects of triadimefon seed coating formulation (Tri SCF) on wheat seedling growth regulation and control main diseases of winter and spring wheat in Gansu Province. The pot experiment results showed that, triadimefon mixing with seeds had a little influence to germination and growth of wheat seedlings, but using Tri SCF could not only alleviate this influence, but also significantly improve chlorophyll content and root activity. The field tests results showed that, Tri SCF could not reduce the basic seedlings, while control effects on spring wheat stripe rust and powdery mildew at early stage were 76.2% and 77.0% respectively, the rate of yield increase was 8.95%. Control effect on soil-borne winter wheat take-all was 83.6%, the rate of increased yield was 13.09%. Meanwhile and the prospects of wheat seed coating formulation were also concisely discussed in this paper.