Abstract: It is never denied that plant endogenous hormones play crucial roles in plant defense responses. The functions of these hormones are different upon the plant defense to different kinds of pathogens. And the signaling pathways of plant hormones are not exist alone in plant defense responses, but exhibit cross-talk among these pathways. The cross-talk promotes the coordination of different hormones signal in plants to enhance disease resistance, which is efficient strategy to resist different kinds of pathogens invasion. This paper reviewed the progress on functions of six phytohormones in disease resistance and the cross-talk among the signaling pathways of these six phytohormones including salicylic acid, jasmonic acid, ethylene, abscisic acid, auxin and gibberellin.