Abstract: In order to use the corn straw in agricultural production, study on the effects of straw mulching plus nitrogen fertilizer on grain filling rate and grain yield in wheat ‘Zhoumai22’. The results showed that, the total of grain filling followed “slow-fast-slow” variation. The maximum of grain filling rate and the average filling rate of the S+N240 treatment were the highest among the six treatments, the S+N195+C1500 treatment times. Yield, spike number and 1000-grain weight of the S+N240 treatment were the maximum in all treatments, 8661.8 kg/hm2, 50.2 g, 631.5×104 per hm2, respectively, and higher than the first treatment by 12.6%, 12.0%, 9.7%, respectively. Grain number per ear reached the highest values (34.8 grains) at the fifth treatment, and higher than the S+N150 treatment by 10.6%. The highest culms of ‘Zhoumai22’ were the S+N240 treatment, the spikes of S+N195+C1500 treatment was higher than that of other treatments, but the difference was not significant. The results indicated that, straw mulching plus nitrogen fertilizer had significant effects on grain filling rate and grain yield of wheat ‘Zhoumai22’ (P≤0.01), and the S+N240 treatment might be the proper treatment in wheat production.