Abstract: To investigate the role of Cd, water single and combined stress conditions of Arisaema heterophyllum leaves damage and antioxidant enzyme activity, under the different concentration of Cd (200, 400, 800 mmol/L) and water stress (PEG6000 simulation, the concentrations of 10%, 20%, 40%) conditions, this paper studied and compared the malonaldehyde (MDA) and superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) effects of antioxidant enzyme activity in Arisaema heterophyllum leaves. Results showed that in a single or combined stress condition, compared with the control, the content of MDA increased, SOD, POD, CAT showed a trend of first increased then decreased. At the same time, with the level of concentration to play an order of a factor of stress, MDA content in the composite stress showed synergistic effect, SOD, POD, CAT showed synergistic or antagonistic effect.