Abstract: In this study, On basis of our previous works and results, effect of application ratio of Nutrition Regulator(NR) and Nano-Silicon(N-Si) on Heavy Metals(Lead, Cadmium) and potassium content of Tobacco Leaves was conducted through filed experiment.The results indicated that (1) application ratio of NR and N-Si can significantly decrease soil available Pb and Cd contents which were extracted by DTPA, and Pb,Cd content of Tobacco Leaves were decreased; Pb, Cd content of Tobacco was the lowest with NR 46.02 kg/hm2, N-Si 45.00 kg/hm2 treatment; Comparing to the control, the Pb contents of upper, middle, lower leaves have fallen by 53.4%, 30.2% and 39.4% respectively ,and Cd contents of upper, middle, lower leaves were down by 46.8%, 49.7%, 54.6% respectively; (2) The combined application of NR and N-Si can significantly increase the potassium content of flue-cured tobacco; One of the best was the results by treatment 5, the potassium content in the upper, middle and lower leaves was 61.4%, 42.1% and 56.6% more than CK respectively; The potassium content of flue-cured tobacco increased as the order of middle leaves > lower leaves > upper leaves; Both of potassium content of middle leaves and upper leaves have reached the standards(3%) of high quality tobacco leaves.