Abstract: In order to control water and soil loss and maximize the yield-quality of flue-cured tobacco, we studied the effects of three cultivation methods, including conventional tillage, no-tillage, no-tillage and straw mulching, on the losses of soil water and nutrient, yield and quality of flue-cured tobacco. The result showed that no-tillage, no-tillage and straw mulching decreased the loss of soil water than conventional tillage. The runoff was reduced by 9.54% and 26.01% respectively. The loss of N, P nutrients was different among treatments, conventional tillage＞no- tillage＞no- tillage and straw mulching. Compared with conventional tillage, the loss of total nitrogen was 13.68% , 39.59% , the loss of total phosphorus was 9.72% , 27.57% respectively. The yield and quality, chemical composition were improved with no-tillage. The benefit of notillage and straw mulching was 5822.85 yuan/hm² more than conventional tillage. Studies had shown that notillage, no-tillage and straw mulching could effectively decrease surface runoff. They were effective ways to reduce soil nutrients loss. No-tillage and straw mulching had obvious yield and value increasing effects, and had high extension application value.