Abstract: In order to identify the responses and change trends of temperature and precipitation in regional area under global climate change, methods of linear trend, 5-years moving average methods, Mann-Kendall nonparametric test, moving t-test were employed to examine temperature and precipitation change trends, mutation in temperature and precipitation at inter-annual and seasonal scales across the Shaanxi Province during 1960 to 2009. Results showed that, the characteristics of temperature at inter-annual and seasonal scale were average temperature of annual, spring, autumn and winter increased significantly, earlier warming mutation in winter and autumn from 1960 to 2009 in Shaanxi Province. The characteristic of precipitation at inter-annual and seasonal scale was annual rainfall, spring rainfall and autumn rainfall reduced significantly, while summer rainfall and winter rainfall increased significantly. And spring rainfall mutation with reducing late, while summer rainfall mutation with increased earlier was characterized. The inter-annual and seasonal change trends of temperature and Precipitation in Shaanxi Province were consistent with the overall trends of climate change in China.