Abstract: In order to study variation of drought-wet condition in Shihezi Region, and based on daily precipitation, mean temperature, maximum temperature, minimum temperature, sunshine duration, wind speed data of 5 stations in Shihezi Region from 1954 to 2012, the change trend, the abrupt characteristic and the period of inter-annual, decadal, seasonal and monthly CI were characterized by using trend analysis, Mann-Kendall and wavelet analysis method. The results were as follow: (1) the decadal and inter-annual CI of Shihezi Region presented increasing trend, with the rate of 0.08/10 a, 0.05/10 a, 0.08/10 a, 0.09/10 a and 0.11/10 a, respectively. The frequency of drought events during the 60s and 70s were more than the period from 80s to 2012. (2) The inter-annual CI of autumn, winter had abrupt change, whereas in spring and summer, it had no abrupt change. The significant period exited in the CI of four seasons, but not happened in the inter-annual CI.