Abstract: For the outstanding problems of drought, hot, cold, diseases harm and lodging, sprouting et al in the wheat production and consumption needs in Guanzhong region, the new variety with high-yield, multi-anti, high-quality needs to be developed. Using Taigu genetic male-sterile wheat as genetic background, through a combination of complex crosses, recurrent selection and pedigree selection, by means of different priorities in the genes′ accumulation and traits′ selection, several excellent traits′ aggregation are to be created and the breeding process is to be shorten. The results showed that the bred cultivar ‘Shaan512’ had some excellent characters as follows: (1) high and stable yielding, its yields came out top in the regional tests of Shaanxi Province for 3 years and exceeded 9750 kg/hm² for many times in the demonstration fields; (2) the new cultivar had more comprehensive resistances and wide range of adaptability, such as enough resistances or tolerances to drought, hot, cold harm and powdery disease, lodging, dry-hot wind and pre-harvest sprouting, longer leaf functional period and fully filling; (3) the new cultivar demonstrated fine appearance quality and cooking quality like big-kernel, excellent commodity of appearance, strong gluten, fine palatability. In the technical innovation of the ‘Shaan512’ breeding strategy: (1) the SDS-PAGE and A-PAGE sequences were perfected, read and evaluated, the positive effect of HMW-GS 14 15 were found and applied; (2) the cross-making methods and selection techniques in character aggregation by Taigu genetic male-sterile wheat were innovated, the shorter breeding record of 7 years from combination-making to variety certified were created; (3) the technical problems that high-yield and high-quality were difficultly united with multi-resistances in the large-spike, big-kernel variety were resolved to certain degree.