Abstract: The study aims to select high-yield and high efficiency rice varieties that suit to be planted in Southern China. A field experiment was conducted with 56 rice genotypes of 8 rice categories under the same fertilizer application in south China rice production regions. N, P, K absorption characteristics of different rice varieties in growth process and yield differences were analyzed. The results showed that: the accumulation of rice dry matter and P, K mainly concentrated in the period of tillering - full heading, N accumulation concentrated in the two periods of seedling-tillering and tillering-full heading. The grain yield, straw yield, total N, P accumulation of two-line late-maturing rice type and the total K accumulation of two-line earlymaturing rice type were the highest, increased by 101.2%, 40.9%, 85.0%, 48.1%, 47.5% compared with conventional early-maturing rice, which was the lowest. The grain yield and N accumulation of the same series of rice increased with the extension of the growth duration. In the period of tillering-full heading, the rice yield had the highest correlation with each period of the total N, P, K accumulation. The nutrient use efficiency of two-line early-maturing rice type was the lowest, for producing every 100 kg rice with N of 2.15 kg, P2O5 of 0.53 kg and K2O of 3.61 kg. The N, P nutrient use efficiency of three-line medium-maturing rice type was the highest, and the highest K nutrient use efficiency was three-line late-maturing rice type. In conclusion, the high-yield and high efficiency rice varieties that suit to be planted in southern China was two-line latematuring rice type and three-line medium-maturing rice type, and nutrient supply at tillering -full heading stage during the rice growing period could improve rice yield.