Abstract: The study aims to guide the reasonable cotton fertilization and evaluate the effect of different fertilization types on the cotton growth and fertilizer utilization in the Yellow River Delta coastal saline area. Five fertilizer types, which were ordinary compound fertilizer, ordinary organic- inorganic mixed fertilizer, homemade organic-inorganic mixed fertilizer (large and small) and the double-coated slow-release organicinorganic compound fertilizer (DSCF), were selected to test the above mentioned effect under the same N, P, K amount. DSCF and small particles homemade fertilizer showed better results. Compared with ordinary organic-inorganic mixed fertilizer, the two treatments increased N, P, K apparent efficiency by 7.9 and 4.2, 2.2 and 1.6, 3.3 and 0.5 percentage points, respectively, and also increased N, P, K accumulation of cotton vegetative organs and genitals. Under the two treatments, the seed cotton yield increased by 11.98% and 7.39% , respectively; and the lint yield increased by 11.83% and 7.29%, respectively.