Abstract: In order to analyze the spatial-temporal variation of temperature and precipitation in Shandong Province and its response to ENSO events, based on the SSTA and SOI data which characterize the ENSO events, and temperature and precipitation data derived from 18 meteorological stations in Shandong Province from 1961 to 2012, we used the climate tendency rate and the moving average, Mann-Kendall mutation test, inverse distance weighted interpolation method and correlation analysis to analyze spatial-temporal characteristics of climate change of Shandong Province, and its correlation with ENSO event. The results showed that: (1) annual and seasonal temperature of Shandong Province showed significant fluctuation and rising tendency from 1961 to 2012, and warming mutation occurred in 1988, the annual temperature increased at a rate of 0.025℃/a, winter’s warming trend was most obvious at a rate of 0.04℃/a; annual and seasonal precipitation decreased in fluctuation, annual precipitation decreased at a rate of -1.60 mm/a, and the largest decrease occurred in summer at a rate of -1.07 mm/a; besides, both the temperature’s increase and precipitation’s decrease showed the characteristic of coastal regions greater than inland areas, mountainous areas greater than plain areas; (2)the correlation between the intensity of ENSO events and temperature changes of Shandong Province was not significant, but there was significantly negative correlation between theintensity of ENSO events and precipitation, and the effect of moderate and severe intensity ENSO events on the annual precipitation was more pronounced; (3)the impact of the intensity of ENSO events on temperature spatial distribution showed decreasing trend from northwest to southeast roughly; and its effect on precipitation decreased from the coastal to the inland, and was affected by higher terrain factors, reflecting the non-zonal characteristics.