Abstract: Experiment on flue-cured tobacco variety ‘Zhongyan 103’ was carried out in Panzhihua Area for the aim of researching the suitable planting patterns of this variety. Two factors random configuration design was used to study the effect of 3 planting densities and 3 kinds of leaves-keeping number of this variety on biological yield and output value. The effect on plant growing, area, dry weight of leaves was also studied. The results showed that the individual weight of leaves significantly reduced with the density increase. Leaves area of lower and middle part of plant increased, yield and output value increased in this case, but superior rate declined, there was no significant change on medium to superior rate in this case. The length and width of upper part leaves reduced significantly with the leaves-keeping number increase. When leaves-keeping number was 20 pieces, it could have the highest yield and output value, the highest rate of superior and medium to superior level’s production. In general, the planting pattern of planting distance at scope from (1.2 m× 0.5 m) to (1.2 m× 0.4 m) with leaves-keeping-number of 20 pieces was the appropriate condition under this experiment, it could get the highest rate of middle to superior, could harvest good quality and suitable yield tobacco.