Abstract: In order to verify synthetic solution scheme of diseases and pests on single cropping rice, application technology of diseases and pests control at key nodes was researched based on data from forecast and control of local rice diseases. The result showed that, when the compound pesticide of 40% chlorantraniliprole-thiamethoxam WG (150 g/hm²) 50% pymetrozine WG (225 g/hm²) 32.5% difenoconazole-azoxystrobin SC (450 mL/hm²) was applied at rice key nodes (the late tillering stage and 5 d before rupture stage), the rice planthopper, sheath blight and Cnaphalocrocis medinalis preventing efficiency at 35 d after the second spray reached to 94.3%, 99.0% and 95.6%, respectively. More importantly, the compound pesticide had long residual activity and excellent safety. Rice stem stayed green, elastic and had few yellow leaves at stem base. Therefore, spraying pesticides at key nodes was able to enhance main economic characters remarkably and to control main diseases and pests effectively on single cropping rice. The synthetic solution scheme had good popularization and application prospect in coastal?areas, which suffered typhoon easily.