Abstract: In order to find out the best combination of water and fertilizer in the production of rambutan and to achieve the goal of saving fertilizer and maintaining high yield and good quality, a field plot experiment was carried out in Baoting county to investigate the effects of drip fertigation and farmer’s practice on rambutan yield, fruit quality and economic benefit. The experiment included three treatments: no fertilizer (CK), farmer’s practice (FP) and drip fertigation (DF)．The results showed that the yield of DF was 5570.4 kg/hm², fruit total soluble solid was 21.7%, vitamin C was 44.66 mg/100 g and the TSS-acid ratio was 68.49, increased by 24.84%, 9.60%, 25.20% and 31.21% respectively than those of FP. The total titration acid of DF was 0.36%, 13.19% lower than that of FP. Applying drip fertigation could increase the net income by 14362 yuan/hm², reduce the use of N, P₂O₅ and K₂O by 44.57%, 21.89% and 9.63% respectively, and promote the vario-cost ratio from 1.91 to 2.81 compared with FP. The treatment of DF was most conductive to the yield, quality and nutrient uptake and use efficiency of rambutan. Drip fertigation is a suitable model for rambutan cultivation in hilly districts since it can enhance the growth of crops, increase the yield, improve the quality of crops, lower production costs as well as increase the economic benefits.