Review on Host Immune Regulation by Helminth and Its Products

doi:10.11924/j.issn.1000-6850.casb15050054

Abstract

Abstract: The article expounded the molecular mechanism of helminth, its products regulating the host immune system and the potential ability in disease treatment. Host immune regulation is conducted by the increase or decrease of immune cells and up or down expression of cytokines stimulated by helminth and its products. The immune regulation process is closely related to the secreta generated after the invasion of helminth. Secreta of helminth act on immune cells selectively after infecting the host, stimulate the host immune system response and enhance or suppress the immune related factors to implement the immune regulation. The chronic infection of helminth can regulate inflammatory bowel disease, allergic disease and diabetes, and this type of infection shows negative correlation with these diseases to some extent. In summary, understanding the regulation of helminth and its products and elucidating immune regulation mechanism will lay foundation for drug research and development of autoimmune disease treatment.

Sun Shumin,Gao Zhigang,Du Liyin and Dong Yanxin. Review on Host Immune Regulation by Helminth and Its Products[J]. Chinese Agricultural Science Bulletin, 2015, 31(32): 16-21.

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