Abstract: In order to assess the applicability of four kinds of drought indexes in Hexi Corridor regions, the indexes were calculated with the data of 12 meteorological sites in Chinese Meteorological Administration in Hexi Corridor from 1960 to 2013, and the applicability was assessed according to The Chinese Meteorological Disasters Encyclopedia. The results showed that: (1) on the annual scale, the drought grades assessed by Pa and MI were higher than the observation data, the simulating ability of SPI and SPEI was relatively good; on the seasonal scale, the judgment result of SPEI was more close to the actual situation; (2) wetting tendency had different degrees in some regions assessed by Pa, SPI and MI, but drying tendency showed in Hexi Corridor assessed by SPEI; (3) Pa, SPI and SPEI had the same drought frequency; the adaptability and reliability of MI were relatively poorer in drought area; (4) the correlation between the SPEI and MI in the arid Shule river basin was relatively poor; (5) compared with the actual drought records, the error rates of the four indexes followed the order of MI＞SPI and Pa＞SPEI.