Abstract: This study was designed to explore and optimize the technique of combinative application against the major diseases and insect pests of rice, which would provide data for decreasing the input of chemical pesticides and improving the benefit of rice production. The experiments of combinative application of pesticides were carried out to evaluate seedling quality, controlling effect, population dynamics of spider, yield, cost and economic benefit in early rice, single-season late rice and continuous cropping late rice production, respectively. The results showed that the combinative application of pesticides can effectively control the sheath blight, rice hopper, rice leaf roller and stem borer, reduce 2 or 3 times of spray, decrease 20.88%-56.85% input of pesticides, and can improve seedling quality, promote rice growth, maintain the balance of spider population dynamics, increase of rice yields of 483.30-945 Kg per hm₂, increase of benefit of 1186.05-3690 yuan RMB per hm₂ at same time. It was effective demonstrated that to implement the plan of combinative application of pesticides can decrease the input of chemical pesticides, realize the agricultural production and gain the satisfied economic, social and ecological benefits.