Abstract: A pot experiment was conducted to study the effect of ree fertilizer on growth and development of tobacco and its preventive effect on Cd uptake by adding exogenous Cd to soil. The results showed that Cd stress inhibited the growth and development of tobacco, decreased the uptake of nitrogen, phosphorus, potassium, calcium, magnesium and zinc, but promoted the uptake of copper. When the application amount of ree fertilizer was 0.4 g per kilogram soil (900 kg/hm²), the inhibition effect of Cd stress on the growth and development and nutrient absorption of tobacco were relieved, and Cd concentration in tobacco leaves decreased. When the Cd added concentration was 1.2 mg/kg, Cd concentration in middle-lower leaves decreased by 19.7% compared with that of CK. When the application amount of ree fertilizer was 0.4 g per kilogram soil (without adding exogenous Cd), the uptake of cadmium, zinc and copper decreased and the uptake of potassium increased, the contents of Cd in the upper and middle-lower leaves decreased by 23.4% and 7.84%, respectively, but the contents of potassium increased by 14.1% and 9.51%, respectively, compared with that of CK. The distribution of Cd in tobacco was middle-lower leaves＞upper leaves＞stalk.