Abstract: The paper aims to study the correlation of formic acid content of hops and meteorological conditions in the Hexi Corridor. The authors used the formic acid content data of hops (ɑ -acid) in Yumen Town, Gansu in 1989- 2013, and the surface meteorological data over the same period, to analyze the effect of major meteorological factors (temperature, light, precipitation (water) and so on) on formic acid content of hops. The results showed that: the lowest temperature from May to June during vine-budding flowering periods of hops and the formic acid content had a significantly negative correlation; the higher the ≥10℃ accumulated temperature was, the lower the formic acid content of hops was. The more sunlight during mature-picking periods of hops was, the higher the formic acid content was. The relative humidity and formic acid content in germination stage had a significantly positive correlation, the vapor pressure and formic acid content in bud flowering stage had a quadratic relationship. Meanwhile, the authors adopted SPSS statistical analysis software to do the stepwise regression analysis of the formic acid content of hops and meteorological factors, established a prediction model of the formic acid content of hops, which was helpful to practical analysis.