Abstract: The paper aims to study the difference between the observation data of DZZ6 type and CAWS600 type automatic meteorological stations. The authors used the valid data of Xifeng National Basic Meteorological Station, Huan County National Basic Meteorological Station and Heshui County Meteorological Bureau in 2014, to statistically analyze the observation data of air pressure, temperature, humidity, etc. from automatic meteorological stations with DZZ6 ISOS software operation and CAWS600 2004 software OSSMO operation. The results showed that: the two sets of automatic meteorological station data were relatively complete, the rate of measurement lack was low. Through the difference analysis, the consistent rate of the two sets of data was high and the difference of elements was small, meeting the code requirements. The study got the conclusions which were suitable for actual operation, the two sets of the observation data of automatic stations could merge statistically and replace each other without sequence correction; the reason of the difference might be associated with the manufacturer, model and the performance of the instrument, and there was no systematic error.