Abstract: The study aims to identify the effect of new cotton chemical regulators‘Miantaijin’and ‘Quanjingkong’, and confirm their suitable application method in Liaohe basin. A comparison text was conducted to study the development process, boll distribution, boll biomass distribution, yield and its components, and fiber quality of‘Liaomian 30’under the treatment of‘Miantaijin’,‘Quanjingkong’, mepiquat chloride (DPC) and chlormequat chloride. The results showed that the new cotton chemical regulators ‘Miantaijn’and‘Quanjingkong’could help to shape the reasonable plant structure, coordinate boll distribution, optimize boll biomass distribution, prevent premature senility, increase yield, while had no adverse effect on fiber quality, therefore, the two regulators could be popularized and applied in Liaohe basin. However, the usage and dosage should be adjusted according to the production practice. Generally, too early regulation was not recommended, the regulation should be controlled lightly in the early stage (bud stage to flowering stage, mid-June to early July), adequately in the medium stage (flowering stage to boll florescence, mid-July to late July), and strongly in the late stage (boll florescence, late July to early August).