Abstract: Through disaster survey of anti-season wax apple under low temperature condition, the authors drew determining meteorological factors of cold injury occurred in fruit stage of wax apple, statistical analysis of the lowest temperature data (1961-2016) in Qionghai were done to explore the regulation of cold injury in the different periods. The results showed that: the daily minimum temperature ≤10℃ could cause significant effect to fruit stage of wax apple, leaves and fruits appearred a large number of loss, the fruit quality reduced; cold injury mainly appeared in late December to mid-February, average annual happened days were 4.7. Thus, wax apple planting in anti-season may occur cold injury in fruit stage every year in Qionghai, so arrangement in fruit mature period before the mid-December would reduce the risk of cold damage probability in fruit stage. The study results for high-yield cultivation of anti-season wax apple and disaster prevention and reduction can provide certain reference value.