Abstract: The observed data of spring wheat from 1986 to 2014 in the agricultural meteorological observation station of Zhangye, Gansu Province and the meteorological data in the same period were used in this study, the effect of cultivar renovation on the growth period and yield of wheat in Hexi area under climate warming was analyzed by the method of correlation analysis, trend analysis and variance analysis. The results showed that the temperature of this area increased significantly in the 29 years and the annual increase rate was 0.81℃/10 a; while the precipitation decreased with the annual decrease rate of 2.09 mm/10 a, the climate tended to be warm. The increase of temperature and cultivar renovation decreased the days of growth period. The analysis of the relationship between yield and climatic factors, yield components and cultivars showed that grain number per spike and cultivar renovation all leaded to the significant improvement of spring wheat yield.