Abstract: To investigate the integration of water and fertilizer, and its effect on tobacco quality and economic benefit, different water and fertilizer management tests were carried out in Luoyang, Henan, which included four treatments:‘Yuyan 6’(DF6) and‘Qinyan 96’(DF96) of water-fertilizer integration and‘Yuyan 6’ (DF6) and‘Qinyan 96’(DF96) of conventional fertilization treatment. The results showed that DF6 and DF96 significantly increased the plant height, leaf area and remained leaf number, increased the output value and reduced the production cost. In addition, it significantly improved flue-cured tobacco appearance quality, such as luster, softness, foliar tissue structure, color and oil and other indicators, coordinated chemistry component in tobacco leaves, and improved aroma components of flue cured tobacco leaf, especially degradation products of cembranoids. Meanwhile, the smoking quality of tobacco was enhanced. Thus, the drip irrigation mode of integration of water and fertilizer could improve quality and economic benefit of tobacco.