Abstract: To investigate the effects of fertilizer reduction and efficiency increase of different formula fertilizers on indica-japonica hybrid rice ‘Yongyou 12’, under the condition of total chemical fertilizer decreased by 10.2%, four formula fertilizers were used as materials, and conventional fertilization was used as CK. The results showed that: rice specific fertilizer (16-10-14) was the best practice with fertilizer cost reduced by 16.90% and rice yield increased by 1.76%, so it was suitable for promotion and application in this area. Then was compound fertilizer (20-12-14), the effect of fertilizer reduction and efficiency increase was not obvious. Compound fertilizer (22-6-12) could save fertilizer cost, but the rice yield decreased. Compound fertilizer (15-10-17) not only raised fertilizer cost, but also reduced rice yield.